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Abstract Nicotinamide adenine dinucleotide (NAD + ) is an important cofactor for both metabolic and signaling pathways, with the dysregulation of NAD + levels acting as a driver for diseases such as neurodegeneration, cancers, and metabolic diseases

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(22) Other studies, however, have shown that supplementation with low-dose cobalamin (B12) on normal subjects did not affect sleep onset time or total sleeping time

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