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The de novo synthesis of serine from 3-PG occurs in a chain of consecutive enzymatic reactions catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1) and phosphoserine phosphatase (PSPH)
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Understanding this axis provides potential targets for developing therapies that disrupt stromal remodeling and enhance the efficacy of cancer treatments
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