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Previously, it was reported that CRS induces TDO expression in the liver and cortex of mice, but it returns to baseline levels after 24 h 36

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Several factors can contribute to histamine intolerance, including:( 3,4) Weak digestion Inflamed intestines Bacterial infections (especially in the gut) Eating things that harm your gut, such as processed food Food allergies and food intolerances (especially gluten and cow dairy) Microbiome imbalance Nutrient deficiencies An overactive immune system Weakened adrenals (low cortisol) Chronic viral infections Mold exposure Fragrances Mood imbalances Overtraining and excessive exercise High estrogen levels If your body isn’t effectively clearing histamine, it continues to circulate, causing widespread discomfort