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Anti-Apoptotic Effects Cerebrolysin protects neurons from programmed cell death (apoptosis) through multiple mechanisms: upregulation of anti-apoptotic proteins such as Bcl-2 and Bcl-xL, downregulation of pro-apoptotic proteins including Bax and caspases, protection of mitochondrial membrane integrity and prevention of cytochrome c release, and reduction of oxidative stress and free radical damage that trigger apoptotic cascades
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