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Back in 1985, Blass and Coleman reported on the increased levels of lactate in the plasma of four autistic patients and suggested that this was a result of aberrations in OXPHOS [65]

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Figure 2 4.4 Metabolic crosstalk between hepatocellular carcinoma cells and tumor infiltrating lymphocytes The metabolic reprogramming of T cells occurs during their self-activation process, transitioning rapidly from the characteristic metabolism of Tn cells, oxidative phosphorylation (OXPHOS), and fatty acid oxidation (FAO), to the characteristic metabolic processes of Teff cells, glycolysis and glutamine decomposition, in order to sustain growth and proliferation (159)