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Several studies have demonstrated that metformin’s stimulation of autophagy can result in increased apoptosis in cancer cells ( Moreover, metformin’s interactions with autophagy in glioma can be further supported by evidence showing that the drug, in combination with other therapies, can alter the tumor microenvironment ( 2.3 Necrosis Research has increasingly focused on the role of necrosis, especially necroptosis, in metformin’s therapeutic efficacy against glioma cells (37)

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