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The uremic toxin indoxyl sulfate accelerates senescence in kidney proximal tubule cells

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Further, BHB’s neuroprotective properties stem from (among other actions) an interaction with the hydroxycarboxylic acid 2 (HCA2) receptor (or GPR109A, also known as NIACR1 or the niacin receptor 1, and encoded by the HCAR2 gene), a G protein-coupled receptor found on adipocytes, neutrophils, tissue macrophages, and in the anterior cingulate cortex (Rahman et al., 2014)