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Notably, TDO2 has been reported to be expressed in different cancer cells, including breast, ovarian, glioma, and hepatic carcinoma [74,95,96]
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Thus, despite increased claudin-2 expression in human disease 64,86,87,92,175,176 and experimental data showing that claudin-2-dependent pore pathway permeability increases exacerbate disease in mice 50,98,100 , the relevance of claudin-2 to human intestinal disease remains to be determined
massaging it gently until fully absorbed