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In Apoe −/− mice with established atherosclerosis that were fed the SD, DT-109 treatment significantly increased the expression of Gstt2 and Gstt3 (Fig

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For instance, astrocytes were reported to help increasing the expression of HO‐1 in microglia, decreasing the production of microglia‐derived ROS, thereby inhibiting excessive inflammation of CNS.80 Nrf2‐Keap1‐ARE, a main endogenous antioxidant stress signalling pathway, is also known to be an important anti‐inflammation pathway