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The field is young, but ALS patients might one day receive personalized microbiome-based adjuncts – for example, a consortium of bacteria tailored to produce neuroprotective metabolites or to reduce neurotoxic ones – as part of a broader therapeutic regimen

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Degradation of elastin fiber, collagen accumulation, cellular element restructuring and calcium accumulation in the vascular wall, as well as arterial stiffness leads to mechanical adaptation of the arterial wall triggered by hypertensive heart disease [36]