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The protective effects of antioxidants against oxidative damage have garnered significant attention in fields such as biology, medicine, nutrition, and agrochemistry (Magalhaes et al

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4-Aminoantipyrine in combination with a phenolic compound as peroxidase substrates In 1969, Trinder proposed the use of 4-aminophenazone, later replaced by 4-aminoantipyrine (4-AAP), together with phenol as a non-carcinogenic alternative to o -dianisidine (Trinder 1969)