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Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility | Cell Death Discovery

The decline in estrogen during menopause, therefore, disrupts these intricate mechanisms, leading to a range of cognitive and emotional changes

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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3β-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

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