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doi: 10.1146/annurev.immunol.15.1.351 191 LeiHWangGZhangJHanQ

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Histopathological examination of the hepatopancreas showed atrophied R-cells, severe necrosis and shrinkage of the tubules, infiltration of haemocytes and fibroblastic cells that produced a fibrosis-like exterior aspect, cell degeneration and pyknotic nuclei in the lumen, spread necrosis and complete destruction of B cells, complete isolation of connective tissue from hepatopancreas tissue and in midgut tissue and separation between mucosal and submucosal layers (Ghaednia et al., 2013)