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First, by immunostaining of phosphorylated eNOS (p-eNOS), the active form of eNOS (16), we examined the activity of eNOS in skin and found that the percentage of p-eNOS–positive endothelial cells was significantly increased in the skin of mice treated with glutamic acid and aspartic acid (Figure 4, A and B)

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10.1016/j.neuron.2013.12.018 Neuron 3 AndresA