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477 Similarly, other types of lymphocyte-B cells have been investigated to determine whether restoring B cell production in the bone marrow or reconstructing the peripheral B cell repertoire could enhance the immune responsiveness of elderly individuals to neoantigen challenges (NCT00863187) (Table 2)
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Specifically, a decrease in Firmicutes coupled with an increase in Bacteroidetes can enhance IgA secretion in the intestinal mucosa, inhibit pathogenic bacterial colonization, and protect the intestinal mucosal barrier through symbiosis with the host
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