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Trazodone is also an antagonist at several other monoaminergic receptors including 5-HT 2B (Ki = 78.4 nM), 5-HT 2C (Ki = 224 nM), α 1A (Ki = 153 nM), α 2C (Ki = 155 nM) receptors and it is a partial agonist at 5 HT 1A (Ki = 118 nM) receptor
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High Tolerability: In human trials involving over 900 subjects, no anti-peptide antibodies or significant adverse events were reported
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