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86 Enzymes that appear to be regulated by direct binding of Cu including mitogen-activated protein kinase kinase 1/2 (MEK1/2), which is required for downstream phosphorylation and activation of ERK1/2 and thus potentiation of the mitogen-activated protein (MAP) kinase pathway indeed, the MAP kinase pathway is a significant repository of oncogenic mutations and a long-standing target of cancer therapies (Figure 5B)

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