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Treatment of the 3xTgAD Alzheimer’s disease model mice with ketone ester [(R)-3-hydroxybutyl-(R)-3-hydroxybutyrate], which is metabolized into two molecules of the ketone body beta-hydroxybutyrate, increased the cerebral cortical cytoplasmic [NAD + ]/[NADH] by 70% (from 230 to 390) and increased the hippocampal [NAD + ]/[NADH] by 65% (from 250 to 410), as inferred from the increased pyruvate/lactate (Pawlosky et al., 2017)
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