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Common loading phase A commonly discussed experimental loading phase is: 2–2.5 mg per administration Twice per week Four to six weeks Common maintenance phase After the loading period, commonly circulated maintenance protocols may reduce the amount to: 2–2.5 mg once weekly Or 2–2.5 mg once every two weeks Maintenance practices vary significantly and are not supported by standardized human dose-ranging studies

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Furthermore, a robust IFN-I response mediated by cGAS activation has been observed in several NDDs during their progression, likely triggered by cellular stress or death