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When extreme cold contacts the skin, blood vessels constrict dramatically in a process called vasoconstriction

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Innate immune cells, such as neutrophils, macrophages and their CNS counterparts, microglia, mast cells, innate lymphocytes [e.g., interleukin (IL) -17-secreting γδ Tregs (T cells)], natural killer Tregs, respond within hours and subsequently activate T and B lymphocytes (Lee and Kim, 2017)