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Both in vitro and in vivo assay demonstrated that METTL14 induced N6 -methyladenosine (m 6 A) modification at 5′UTR of SLC7A11 mRNA, which promotes SLC7A11 mRNA stability and upregulates its expression by inhibiting the deadenylation process, enhancing ferroptosis resistance (Liu L

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JAK2 disease-risk variants are gain of function and JAK signaling threshold determines innate receptor-induced proinflammatory cytokine secretion in macrophages

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