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Notably, mutation of A 5.65 into valine has a lesser impact on the activation potency of dopamine, whereas it significantly decreases with leucine substitution due to the side chain of leucine forming steric clashes with the hydrophobic pocket of G s [142]
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These discrepancies underscore the need for further research to elucidate the potential therapeutic role of NAC in MASLD and NAFLD, particularly in considering variations in dosage, treatment duration, and patient characteristics
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