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Although traditionally associated with neuronal neurotransmitter metabolism, MAO-B is expressed predominantly (if not exclusively) in astrocytes, where it plays a central role in reactive astrogliosis and neuroinflammation 345,346

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Additionally, in the context of mitochondria, mitoquinone mesylate (mitoQ) and 2,2,6,6-Tetramethylpiperidine 1-oxyl (mitoTEMPO) have been reported to act as mitochondria-targeted antioxidants