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96 participants were randomly assigned to groups of 6 multiple-ascending doses of once-weekly subcutaneous cagrilintide (final doses of 0.16, 0.30, 0.60, 1.2, 2.4, and 4.5 mg) in combination with once-weekly subcutaneous semaglutide 2.4 mg or semaglutide 2.4 mg with placebo for 20 weeks