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Excessive •O 2 − irreversibly oxidizes and degrades iron-sulfur clusters in core metabolic enzymes, such as aconitase and site I Q , disrupting ATP synthesis and anabolic precursor supply [88]
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These fibroblasts in the tumor milieu are also called “CAFs.” Additionally, CAFs can transdifferentiate from other cells, such as pericytes, epithelial cells and ECs, via exposure to platelet-derived growth factor (PDGF), tumor-derived transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), MMPs and reactive oxygen species (ROS) (Yu Y