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Specifically, SHANK3 plays a pivotal role in regulating glutamatergic synapses, maturation of the dendritic spine, and strengthening the formation and transmission of synapses via glutamate receptors such as AMPARs and NMDARs

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25 Additionally, calcium levels were found to be elevated in inflammatory macrophages 13 and lysosomal calcium trafficking has been shown to regulate dendritic cell migration, 309,310 further supporting the central role of calcium in immunity