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However, in in vitro , among trivalent arsenic species (i.e., iAs III , MMA III and DMA III ), the methylated MMA III has shown much stronger binding affinity for various proteins including Zinc finger proteins or PML-RARα fusion proteins as compared to other two arsenic species (Figure 7) [131], but methylated arsenicals were incapable of inducing protein degradation, suggesting that arsenic induced PML-RARα fusion protein degradation is complicated
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