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Immunocytochemical studies on the expression of GSTA4-4 Figure 14a shows an increased expression (immunofluorescence) of GSTA4-4, an oxidative stress specific GST isoenzyme, in HepG2 cells after ASA treatment.NAC treatment brought the enzyme activity close to control values in 5 µmol/ml ASA treated cells but not in 10 µmol/ml ASA treated cells, where the enzyme expression remained significantly higher

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They are generally safe but work as ongoing supplements that must be taken continuously