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The binding energy values for both compounds were better, when compared to allopurinol, but not so far apart (−6.7 and −6.2, for 70 and 71 , and allopurinol, −6.1), as other interactions may have stabilized the complexes between the compounds and the XO binding site
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However, recent studies show mild hypoxia in developing mouse hearts does not induce VEGF-A or coronary angiogenesis, 453 suggesting other factors
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