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The overexpression of arginine methyltransferase 5 (PRMT5) in solid and hematological tumors leads to the elevation of the methylation level of arginine residues on functionally related proteins in tumor cells, which affects cell cycle regulation, mRNA splicing, cell differentiation, signal transduction, and other physiological processes
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The enhanced weight loss observed in response to GLP-1–MK-801 coincided with a more pronounced decrease in food intake within the first 48 h after the infusion relative to semaglutide-treated mice (Fig
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