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For example, older people frequently have a problem with low acid levels in their stomachs

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3.3 Role of CCL25/CCR9 chemokine/receptor axis in the development of mucosal tissues-resident CD4 + and CD8 + T cells Naive CD4 + and CD8 + T cells require activation in lymphoid tissues before differentiating into effector or memory T cells capable of trafficking to nonlymphoid mucosal tissues (141, 142)