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Safety considerations also arise: Ashwagandha has occasionally precipitated thyrotoxicosis, and curcumin may interact with anticoagulants (41, 42, 235)

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Additionally, members of the ENPP family influence neuroprotection and damage responses by regulating autophagy and generating lysophosphatidic acid (LPA), which affects neuronal signaling in neurodegenerative diseases [77]

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