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52 Another disc needle puncture study in mice has shown that 1 year after IVD degeneration induction, cold hypersensitivity (as indicator for radiating pain) persisted and was shown to be correlated with disc height, in a subset of the animals, whereas axial pain‐behaviors such as tail suspension and grip strength did not

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Beta-adrenergic GPCRs couple to a stimulatory G-protein, or G s , which initiates the cyclic AMP (cAMP) second messenger system by activating the enzyme adenylyl cyclase