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Approaches to past research include analyzing the aqueous humor, which is thought to be a useful way to discover specific molecules that contribute to glaucoma pathophysiology, and a proteomic approach, which has been used to identify proteins that are candidates for making prognoses in glaucoma pathogenesis
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The p38/MAPK pathway is activated, and the c-Jun N-terminal kinase (JNK) and extracellular regulated protein kinases (ERK) pathways may also be activated, and high fluoride concentrations have a substantial inhibitory effect on mouse B lymphocytes, reducing the proliferative activity of lymphocytes, indicating that sodium fluoride (NaF) may inhibit the proliferation and differentiation of lymphocytes via the p38/MAPK pathway (58–61)
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