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The total alkaloids of Rhizoma Corydalis effectively reduce NLRP3-induced ferroptosis, alleviate pathological damage in the hippocampus of diabetic rats, and thereby improve cognitive function [164]

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Keap1 ), the negative regulator of Nrf2, in ArcAβ42 flies, activated Nrf2, induced Aβ42 degradation, prevented neuronal toxicity in response to Aβ42 peptide, rescued neuronal-specific motor defects and increased life span (Kerr et al., 2017)