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For example, individuals with Leber’s disease, a rare genetic disorder, may be at risk of optic nerve damage from B12 injections
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In published preclinical work, inhibiting NNMT is associated with elevated intracellular NAD⁺ and SAM, reduced lipogenesis and smaller adipocytes in cell and diet-induced-obese rodent models, and is studied in the context of insulin sensitivity and muscle function
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