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2.3.2.4 Effects of PA on liver fibrosis It has long been thought that PA was effective in the treatment of chemical-induced liver fibrosis in rats and the primary mechanisms of this therapeutic effect could be due to its protection against hepatic injury by reducing serum levels of ALT and AST, as well as its induction of apoptosis in activated HSC by downregulating bcl-2 mRNA expression (Zhang Y
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