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Immunosuppressive cells within the tumor microenvironment disrupt T cell activation and proliferation by increasing the expression of immunosuppressive receptors such as PD-1 and CTLA-4 and by releasing immunosuppressive cytokines like IL-6, IL-10, TGFβ, and VEGF (Mariathasan et al., 2018

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Post-hoc analyses from clinical trials show tirzepatide may reduce high-sensitivity C-reactive protein (hsCRP) levels, though reductions appear to correlate with weight loss and improved glycemic control