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Upon delivery of B12 to the tissues by holo TC, receptor-mediated endo­cytosis occurs, after which holoTC enters acidic lysosomes where the trans­cobalamin protein is degraded, the B12 is released, and then converted to its cofactor forms (Allen et al., 2018)

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SCD1 inhibits the production of fatty acids and lipids, which in turn triggers iron-transport-induced cell death in OCSCs (89)