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This may be attributed to enhanced signaling levels of GMP-PKG that increase the concentration of phosphodiesterase 2 and NOX2-dependent mechanisms that are correlated with the aforementioned diseases and ROS, especially in the pathogenesis of psychiatric disorders 99

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Furthermore, due to deficient GH secretion, the ability of GH to antagonize the anti-lipolytic effect of insulin is reduced, leading to accumulation of visceral adipose tissue (VAT)