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Activation of the NRF2 pathway, including induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), promotes autophagic clearance and restrains over-activation [87] (Fig
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For prevention of contrast-induced acute kidney injury, a meta-analysis found misleading beneficial associations that were lost when analysis was restricted to larger studies (52) , and mechanistic studies showed that oral NAC is poorly absorbed with no renoprotective effects (53)
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