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Among other processes, hypoxia activates the transcription factor hypoxia-inducible factor-1-alpha (HIF-1α), which promotes angiogenesis through multiple mechanisms including the regulation of a large number of angiogenesis related genes [31] and the production of angiogenic growth factors including for Ang-2, stromal cell-derived factor-1 (SDF-1) and vascular endothelial growth factor (VEGF-A) [32]