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In fact, knockdown of PGC-1β impairs not only the metabolic profile of M2 macrophages but also their functions ( Recently, the protein TNF-alpha-induced protein 8-like 2 (TIPE2) has also been associated with an M2 phenotype, through the induction of arginine metabolism, which as already mentioned, is the most distinguished metabolic feature of M2 macrophages

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