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Inhibition of CP by Sulindac was achieved by significantly reducing infiltration of myeloperoxidase-positive neutrophils and Mac-3-positive macrophages in the pancreas, and sulindac treatment also significantly reduced TNF-α and MCP-1 mRNA expression in the pancreas (117)
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For subsequent refills or if you were previously on the medication, follow-ups are required every 6 months
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