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The problem is not the molecule, but what happens when the molecule is damaged—such as oxidized cholesterol—or at such a high level in the body—such as blood sugar higher than 200—that it alters physiology
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Attempts to improve linear growth by rhIGF-I treatment has been reported to result in some improvements in a few affected children but not all (134, 135) It is beyond the scope of this chapter to review the overwhelming evidence from cell biology experiments demonstrating the important role of IGFBPs in modulating IGF bioactivity and the role of IGFBP proteases and their actions at the cellular level
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