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Related studies have shown that intracranial injection of D-serine into the medial entorhinal area (MEA) in the TLE is beneficial to prevent neuronal loss and epileptogenesis by rescuing hippocampal CA1 neurons in the epileptic brain and reducing the number of astrocytes and microglia, thus alleviating the effect of neuroinflammation (Beesley et al., 2021)
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