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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaques—the primary pathological mechanism underlying CAD ( γ (IFN- γ ) and tumour necrosis factor (TNF)- α , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression