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If anything feels unusual, persists longer than expected, or causes concern, it is important to seek clinical advice rather than make changes independently

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This condition also induces an increase in several inflammatory mediators, including the protein levels and mRNA expression of TLR-4, NF-κB, p65, and p38 MAPK, as well as elevated levels of proinflammatory cytokines such as IL-1β, ICAM-1, and TNF-α [ 51 , 52 ]